New research reveals that CBD not only enhances endurance in mice but does so by transforming gut bacteria and optimizing muscle function, offering a potential breakthrough in performance science.
A recent Experimental & Molecular Medicine study determines whether improvements in exercise performance through cannabidiol (CBD) treatment are due to changes in the gut microbiome.
The unique interplay between exercise performance and the composition of the gut microbiota led the current study’s researchers to examine whether CBD improves exercise performance by modulating gut microbial composition in mice.
Herein, 20-week-old male mice were housed under a 12-hour light-dark schedule with food and water available ad libitum. After one week of acclimatization, body fat and lean body mass measurements of the test mice were obtained. The first cohort of mice were orally treated with 30 mg/kg CBD dissolved in corn oil once daily for four weeks or dimethyl sulfoxide (DMSO), which served as the vehicle control.
A second group of mice was used to investigate whether antibiotic treatment influences the CBD effect. To this end, mice were treated with 40 mg/kg doxycycline alone or in combination with CBD, following which treadmill performance was assessed.
Faecalibaculum rodentium or Bifidobacterium animalis was orally introduced once daily for four weeks in the third cohort of mice at a dose of 1 × 108 colony-forming units (CFU).
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